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Discovery of special dendritic cells sheds light on food allergy prevention
2025-04-24 18:45:03| Spiritual Career Counseling
NYU Langone Health / NYU Grossman School of MedicineApr 15 2025The immune system must be able to quickly attack invaders like viruses, while also ignoring harmless stimuli, or allergies can result. Immune cells are known to ignore or "tolerate" molecules found on the body's own healthy cells, for instance, as well as nonthreatening substances from outside the body like food. How the system achieves the latter has been unclear.Now, a new study led by researchers at NYU Langone Health has revealed that a special group of cells in the intestines tamp down the immune responses caused by exposure to food proteins. Called "tolerogenic dendritic cells," these cells enable food to pass through the body without triggering an immune reaction, unless they malfunction to cause allergies.The cells were also found to require the proteins Retinoic Acid-Related Orphan Receptor-gamma-t (RORt) and PR domain-containing 16 (Prdm16) to effectively protect tolerated proteins from the inrush of immune cells...
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