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Potential targeted therapy for pediatric brain cancer identified by Dana-Farber team
2025-04-13 15:45:04| Spiritual Career Counseling
Boston An international team of clinical collaborators, led by physician scientists from Dana-Farber Cancer Institute, performed a first-ever clinical test of the targeted therapy avapritinib in pediatric and young patients with a form of high-grade glioma. They found that the drug, already FDA-approved for certain adult cancers, was generally safe and resulted in tumor reduction visible on brain scans, as well as clinical improvement, in 3 out of 7 patients.The study was published inCancer Cell.Pediatric-type high-grade gliomas are currently incurable brain tumors with median survival times less than 18 months after initial diagnosis.Avapritinib is a small molecule that crosses the blood-brain-barrier and targetsplatelet derived growth factor alpha (PDGFRA), which is overactive in some pediatric high-grade gliomas and leads to uncontrolled growth of cancer cells. The team is now designing a clinical trial of avapritinib treatment for newly diagnosed pediatric patients withPDGFRA-alt... [ more ]
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Why are cryptocurrencies down today?
2025-04-13 11:45:04| Spiritual Career Counseling
The US will impose reciprocal tariffs on international trading partners based on half of each country's respective rates.The baseline tariffs will be 10% on all imports and 25% on foreign-made cars.Bitcoin and other top cryptocurrencies, including Ethereum, Solana and XRP, saw major declines following the tariff announcement.Bitcoin (BTC) and the entire crypto market saw a quick correction on Wednesday following President Donald Trump's reciprocal tariff announcements based on half of each country's respective rates. The tariffs also include a 10% baseline tariff on imports and 25% on foreign-made automobiles.Following the announcement, Bitcoin fell 2% while Ethereum (ETH), XRP and Solana(SOL) noted declines of 4%, 3% and 4%, respectively, according to FXStreet asset price page.Bitcoin, crypto react sharply as Trump tariffs spark market volatilityIn the "Make America Wealthy Again" event at the White House on Wednesday, President Trump announced global reciprocal tariffs ranging from 1... [ more ]
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Employment
CSK vs DC Match Prediction: Who Will Win Today's IPL Match 17 2025?
2025-04-13 11:45:04| Spiritual Career Counseling
Table of ContentsChennai Super Kings (CSK) will lock horns against the Delhi Capitals (DC) in the 17th match of IPL 2025 at the MA Chidambaram Stadium in Chennai. CSK vs DC Match Prediction: Who Will Win Today's IPL Match 17 2025? Match Details Match: Chennai Super Kings vs Delhi Capitals Date: April 5, 2025 Time: 3:30 PM IST Venue: MA Chidambaram Stadium, Chennai Live streaming: JioHotstar Live broadcast: Star Sports CSK vs DC Match PredictionHead-to-Head Record Chennai and Delhi have faced each other in 30 IPL matches so far, with CSK having the upper hand with 19 wins, whereas DC has come out victorious on 11 occasions. Total Matches Played: 30 CSK Won: 19 DC won: 11 CSK vs DC Pitch Report & Conditions The team that wins the toss in the Chennai vs Delhi game will look to bat first, considering the nature of the surface, which tends to slow down while batting in the second innings If we look at the matches played at Chepauk in the last few IPL seasons, the pitch is known for assisti... [ more ]
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Employment